For rarer targetable genetic alterations in ROS1, RET and MET, a similar approach is often used.

对于 ROS1、RET 和 MET 较罕见可靶向遗传改变，通常使用类似方法。

Many are now targetable, but not all targeted therapies have been approved (Figure 7.2).

现许多靶向疗法都是可靶向，但并非所有靶向疗法都已获得批准（图 7.2）。

Molecular testing for targetable gene mutations is critical for treatment selection (see Chapter 7).

针对靶向基因突变分子检测对于治疗选择至关重要（参见第 7 章）。

Most targetable mutations occur in the adenocarcinoma subtype of NSCLC.

大多数靶向突变发 NSCLC 腺亚。

Unlike other targetable oncogene drivers in NSCLC, KRAs G12C is most common in smokers Until recently, KRAS was an undruggable target.

NSCLC 其他靶向基因驱动因素不同，KRA G12C 吸烟者最常见。直到最近，KRAS 仍是一个不可药物治疗靶点。

First tested in 2007, the Yars missile system has a potential range of up to 12 thousand kilometers and can carry six to 10 independently targetable warheads.

亚尔斯导弹系统于 2007 年首次测试，其潜射程可达 1.2 万公里，可携带 6 至 10 枚独立目标弹头。

The best strategy for patients with unresectable stage III NSCLC who harbor targetable mutations such as alterations in the EGFR gene also needs further investigation.

对于携带 EGFR 基因改变等靶向突变不可切除 III 期 NSCLC 患者，最佳策略也需要进一步研究。

The successful application of checkpoint inhibitors in metastatic NSCLC without targetable mutations (see Chapter 6) has inspired ongoing efforts to incorporate the same strategy into the treatment of early-stage disease.

检查点抑制剂无靶向突变转移性非小细胞肺成功应用（见第6章）激发了人们不断努力将相同策略纳入早期疾病治疗。

The majority of patients without a targetable molecular alteration receive immunotherapy-based treatment as first-line therapy, either as a single agent in tumors expressing high levels of PD-L1 or in combination with chemotherapy.

大多数没有靶向分子改变患者接受基于免疫治疗治疗作为一线治疗，或者作为表达高水平 PD-L1 肿瘤单一药物，或者化疗相结合。

A proportion of patients with NSCLC will have somatic genetic alterations that can be targeted by specific molecular compounds, with the list of such 'targetable' mutations growing constantly (see Chapter 7).

一部分非小细胞肺患者将出现可被特定分子化合物靶向体细胞遗传改变，此类“可靶向”突变列表不断增长（见第 7 章）。