The chromosomes uncoil back into chromatin.

体解卷回。

So Informer and Borzoi are like chromatin accessibility forecasters?

所以InformerBorzoi就像可及性预测者？

It is not established, however, that the endonuclease-induced DNA fragmentation itself causes the chromatin condensation.

细胞体积形状的改变部分归因于凋亡细胞内谷氨酰胺转移酶活性的诱导。

The chromatin aggregates peripherally under the nuclear membrane, into well-delimited dense masses of various shapes and sizes.

细胞核本身可能崩解，产生两个或多个核碎片。

Well, researchers have cleverly used Evo2 to design DNA sequences that influence chromatin accessibility, effectively controlling gene expression.

研究人员巧妙地利用Evo2设计了影响可及性的DNA序列，有效地控制了基因表达。

Hold on, Morse code? Like dots and dashes? They're writing messages in DNA using chromatin accessibility patterns?

等等，摩尔斯电码？就像点划？他们正在使用可及性模式在DNA中写入信息？

They found that it binds to chromatin, the compact structure that allows long molecules of DNA to ball up and fit into a tiny cell.

研究人员认为，Dsup作为一种绝缘体，可以保护DNA免受羟基自由基的攻击。

It usually involves several genetic mutations in endometrial cells, including of PTEN, a tumor suppressor gene; PIK3CA, an oncogene; and ARID1A, a gene regulating chromatin structure.

它通常涉及子宫内膜细胞的几种基因突变，包括抑癌基因PTEN、原癌基因PIK3CA，及调控结构的基因ARID1A。

Many different environmental stressors have been shown to alter the chromatin and epigenetic marks of plants, providing evidence within their chromosomes that they do indeed have memories of stress.

许多不同的环境压力因素已被证明可以改变植物的表观遗传标记，从而在它们的体中提供证据表明它们确实具有压力记忆。

These machines are called chromatin remodelers, and the way they work is that they basically scoot the DNA around these histones and they allow new pieces of DNA to become exposed.

这些“机器”被称为重塑器，它们载着 DNA在组蛋白上移动，让新的 DNA 片段暴露出来。

You got it. They assigned open chromatin to represent a dot and closed chromatin to represent a dash.

你明白了。他们将开放的表示为点，将封闭的表示为划。

This is where things get really interesting. Remember our discussion about chromatin accessibility, how tightly or loosely DNA is packaged within a cell, affecting which genes are turned on or off?

事情变得真正有趣的地方在这里。还记得我们关于可及性的讨论吗？DNA在细胞内的包装方式是紧密还是松散，这会影响哪些基因被激活或关闭？

Evo 2 to generate DNA sequences that when analyzed by informer and Borzoi produce the desired patterns of open and closed chromatin, effectively spelling out simple messages in Morse code.

Evo 2能够生成DNA序列，当通过InformerBorzoi分析时，能够产生所需的开放闭合模式，有效地用摩尔斯电码拼写出简单的信息。

They then used a technique called beam search to help Evo2 explore various DNA sequence options and select those that Informer and Borzoi predicted would produce the desired chromatin accessibility pattern.

然后，他们使用一种叫做beam search的技术来帮助Evo2探索各种DNA序列选项，并选择InformerBorzoi预测会产生所需可及性模式的那些序列。

They set a specific chromatin accessibility pattern as their target, like saying, " We want a DNA sequence that will result in open chromatin in this region and closed chromatin in that region."

他们设定了一个特定的可及性模式作为目标，就像说：“我们想要一个DNA序列，它会在该区域产生开放的，在那个区域产生封闭的。”