However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少的结缔组织，致使、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体代谢、源葡萄糖生成胰岛素、血小板、体元素及促进细胞有丝分裂细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗糖尿病是慢性丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能是腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态功能并促进胰岛素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧正常还是在低氧培养条件下，小胰岛在体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐量实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双（胰岛素促泌增敏）的药物适于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素和葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少量的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微量元素促进细胞有丝分裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐量减低中的。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖治疗关键，静滴胰岛素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿病慢性丙型肝炎（CHC）中纤维化进展以对抗病毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态和功能并促进胰岛素的分泌，有良好的降血糖。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论含氧量正常还在低氧培养条件下，小胰岛在体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐量实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素和葡萄糖对脂肪生成的协同效应存在品差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少量的结缔组织，致使内、外泌部得以切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微量元素及促进细胞有丝裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的，无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐量减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿病是慢性丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能是腔隙性脑梗塞的危险因素之。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态和功能并促进胰岛素的泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧量正常还是在低氧培养条件下，小胰岛在体外胰岛素泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛耐实验显示IUGR子鼠对外源性胰岛反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛促泌剂胰岛增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内产热、内源葡萄糖生成胰岛、血小板、体内微及促进细胞有丝分裂细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究前瞻性研究的研究焦点都在于胰岛抵抗在糖耐减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛抵抗糖尿病是慢性丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无应答的危险因。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛抵抗，胰岛抵抗可能是腔隙性脑梗塞的危险因之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生A的产物视黄醛可以增加脂肪组织生成，降低胰岛敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛抵抗(IR)及脂紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态功能并促进胰岛的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧正常还是在低氧培养条件下，小胰岛在体外胰岛分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素和葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微元素及促进细胞有丝分裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛素治疗，此先天可能成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛素其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿病是慢性丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能是腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞态和功能并促进胰岛素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧正常还是在低氧培养条件下，小胰岛在体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐量实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素和葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少量的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微量元素及促进细胞有丝分裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐量减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关，胰岛素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿病是慢性丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能是腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态和功能并促进胰岛素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧量正常还是在低氧培养条件下，小胰岛在体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐量实验显示IUGR子鼠对外源性胰岛素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，胰岛素和葡萄糖对脂肪生成的协同效应存品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少量的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说T2DM物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微量元素及促进细胞有丝分裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此例显示腰荐椎发育不全可能是母亲糖尿所致胚胎变的一种，且无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都于胰岛素抵抗糖耐量减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿是慢性丙型肝炎（CHC）中纤维化进展以及对抗毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存胰岛素抵抗，胰岛素抵抗可能是腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿胰岛素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿小鼠胰岛细胞形态和功能并促进胰岛素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行学杂志》最近发表的一份报告表，吸烟使人们患非胰岛素依赖型糖尿的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；体物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存或不存时）对胰岛内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证，不论是含氧量正常还是低氧培养条件下，小胰岛体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

素耐量实验显示IUGR子鼠对外源性素反应迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有双重作用（素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

同时，素葡萄糖对脂肪生成的协同效应存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

外周仅有极少量的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯同时有素促泌剂素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢产热、内源葡萄糖生成素、血小板、体内微量元素及促进细胞有丝分裂细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

显示腰荐椎发育不全可能是母亲糖尿所导致胚胎变的一种，且无论有无接受素治疗，先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因，横断面研究前瞻性研究的研究焦点都在于素抵抗在糖耐量减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴素极其有效。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

外，素抵抗糖尿是慢性丙型肝炎（CHC）中纤维化进展以及对抗毒治疗无应答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙性脑梗塞患者存在素抵抗，素抵抗可能是腔隙性脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低素敏感性。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿素抵抗(IR)及脂代谢紊乱的疗效。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿小鼠细胞形态功能并促进素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行学杂志》最近发表的一份报告表明，吸烟使人们患非素依赖型糖尿的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活性；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对内T细胞活性的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧量正常还是在低氧培养条件下，小在体外素分泌方面由于大，并显示出相对较高的存活率。

However by 8 week IUGR rats developed hyper-insulinemia and high IRI.

胰岛素耐量实验显示IUGR子鼠对外源胰岛素反迟钝。

Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM.

所以，有此双重作用（胰岛素促泌及增敏）的药物适用于T2DM。

In addition, there was breed difference of synergistic effect of glucose of insulin on lipogenesis.

时，胰岛素和葡萄糖对脂肪生成的协存在品种差异。

There is little connective in the peripheryof the pancreas islet,so endocrine portion contacts suff...

胰岛外周仅有极少量的结缔组织，致使内、外分泌部得以充分密切地接触。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models.

这说明在T2DM动物模型中，托吡酯时有胰岛素促泌剂和胰岛素增敏剂作用。

Fructose was mainly used in metabolism in vivo,heat production,endogeny glucogenesis and insulin,platelet,microelement,and promoting cell caryocinesia or cytoprotection.

果糖主要用于体内代谢和产热、内源葡萄糖生成胰岛素、血小板、体内微量元素及促进细胞有丝分裂和细胞保护。

It is suggested that lumbosacral agenesis, a severe congenital defect, might be one of the anomalies of diabetic embryopathy.

此病例显示腰荐椎发育不全可能是母亲糖尿病所导致胚胎病变的一种，且无论有无接受胰岛素治疗，此先天畸形仍可能形成。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和研究的研究焦点都在于胰岛素抵抗在糖耐量减低中的作用。

The key to treatment is to find and cope with shock, dehydration and hyperosmolality, especially to control blood sugar level with insulin.

救治的关键是及早发现并尽快抢救休克、纠正脱水、纠正高渗状态，注意控制血糖是治疗关键，静滴胰岛素极其有。

Moreover presence of insulin resistance and diabetes are risk factors for fibrosis progression and nonresponse to antiviral therapy in chronic hepatitis C (CHC).

此外，胰岛素抵抗和糖尿病是慢丙型肝炎（CHC）中纤维化进展以及对抗病毒治疗无答的危险因素。

Conclusion: There is insulin resistance in patients with cerebral lacunal infarction.Cerebral insulin resistance may be one of its risk factors for cerebral lacunal infarction.

腔隙脑梗塞患者存在胰岛素抵抗，胰岛素抵抗可能是腔隙脑梗塞的危险因素之一。

Retinaldehyde (Rald), a metabolite of itamin A, increases the generation of adipose tissue and decreases insulin sensitiity, work conducted in a Harard Uniersity laboratory shows.

哈佛大学研究结果表明，维生素A的代谢产物视黄醛可以增加脂肪组织生成，降低胰岛素敏感。

Abstract: Objective To evaluate the clinical efficacy of dimethyldiguanide and Gliclazide capsule in treatment of type 2 diabetic insulin resistance (IR) and fat metabolism disorder.

目的观察比较二甲双胍格列齐特对2型糖尿病胰岛素抵抗(IR)及脂代谢紊乱的疗。

In conclusion, LBP possess the action of lowing blood glucose, improving morphogeny and function of pancreatic islet B cells and increasing the secretion of insulin in NIDDM mice.

枸杞多糖可以改善Ⅱ型糖尿病小鼠胰岛细胞形态和功能并促进胰岛素的分泌，有良好的降血糖作用。

A report recently published in the American Journal of Epidemiology suggested that smoking increased the risk of developing non-insulin-dependent diabetes mellitus (NIDDM) by more than three times.

美国《流行病学杂志》最近发表的一份报告表明，吸烟使人们患非胰岛素依赖型糖尿病的危险增加了3倍多。

In vitro antigen presentation assays, in vivo administration of the bromodeoxyuridine coupled to flow cytometry assays assessed intra-islet T cell activation in the absence or presence of B cells.

离体实验测定抗原呈递活；在体动物实验，用溴脱氧尿苷处理后以流式细胞术检测B细胞（存在或不存在时）对胰岛内T细胞活的影响。

Our results provide evidence that small islets are superior to large islets with regard to in vitro insulin secretion and show a higher survival rate during both normoxic and hypoxic culture.

结果证明，不论是含氧量正常还是在低氧培养条件下，小胰岛在体外胰岛素分泌方面由于大胰岛，并显示出相对较高的存活率。